Avigdor A, Bulvik S, Levi I, Dann EJ, Shemtov N, Perez-Avraham G. Engert A, Haverkamp H, Kobe C, Markova J, Renner C, Ho A. those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). Informed consent was obtained from all subjects involved in the study. Lancet Oncol. Disclaimer. PET/CT, however, is time Meignan, M., Gallamini, A., Meignan, M., Gallamini, A. Meignan, M.; Gallamini, A.; Meignan, M.; Gallamini, A.; Haioun, C. Report on the First International Workshop on Interim-PET-Scan in Lymphoma. Med. 2022 Oct;29(10):6254-6264. doi: 10.1245/s10434-022-12191-y. Hodgkin lymphoma is treated with combined chemotherapy with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), Stanford V (a chemotherapy regimen consisting of mechlorethamine, doxorubicin, vinblastine, vincristine, bleomycin, etoposide, and prednisone), or BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) with radiotherapy. Conceptualization, S.N.N. The feature median showed a high sensitivity for DS4+ manifestations on both scanners (scanner A: 0.91, scanner B: 0.85). 2023 Standard of Care. Google Scholar. Flechsig, P. et al. CT radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma manifestations, https://doi.org/10.1038/s41598-022-24227-0. MDPI and/or ; Zucca, E.; Fisher, R.I.; Trotman, J.; et al. Interestingly, even in NECT images, the feature median that ultimately describes the density of a lymphoma manifestation differentiated between DS4-positive and DS4-negative lesions, thereby showing constantly higher values in DS4-positive manifestations (numerical results of the radiomics analysis are provided in the supplementary Table S3; S3a for scanner A and S3b for scanner B). Hasenclever, D. et al. Article B symptoms (fevers, night sweats, weight loss) occur in up to 30% of patients; more common in advanced disease. Breast Implant-Associated Anaplastic Large Cell Lymphoma. Features are extracted from a region of interest (ROI) by mathematical-statistical processing, resulting in many quantifiable features to characterize different image properties10. To further verify the reliability of the results, the number of features was reduced using different techniques. Sau Yip Hui et al., Case Rep, 2022. International validation study for interim PET in ABVD-treated, advanced-stage Hodgkin lymphoma: Interpretation criteria and concordance rate among reviewers. ; Sherbiny, H.S. Would you like email updates of new search results? Patients should receive a 13-valent pneumococcal conjugate vaccine followed by a 23-valent pneumococcal polysaccharide vaccine at least eight weeks later with additional age-appropriate vaccinations because lymphoma is an immunosuppressive condition. EJNMMI Phys 7, 2. https://doi.org/10.1186/s40658-020-0270-y (2020). Disclaimer/Publishers Note: The statements, opinions and data contained in all publications are solely Cheson, B. D. PET/CT in Lymphoma: Current overview and future directions. J Nucl Med 2009;50 Suppl 1:21S-30S. Arai S, Fanale M, DeVos S, et al. Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial. Jorgov, L.; Montravers, F.; Balogova, S.; Ragu, C.; Pacquement, H.; Leblanc, T.; Abbou, S.; Ducou-Lepointe, H.; Landman-Parker, J.; Talbot, J.N. ; All authors have read and agreed to the published version of the manuscript. FDG-PET after two to three cycles of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma. Subsequent chemotherapy toxicities include neuropathy, cardiotoxicity, and secondary cancers such as lung and breast, and should be considered in the shared decision-making process to select a treatment regimen. Results: Among 212 scans assigned DS, 165 scans showed agreement between the DS and line of treatment. Supplementary Tables S3 and S4 provide the full results of the MWU test (S3a,b) and ROC analysis (S4a,b) for scanners A and B. ROC curves of the three first-order features mean, median, and root mean squared(RMS), that concordantly distinguished Deauville score 4-positive and -negative lymphoma manifestations on both scanners. CAS The new staging system incorporates two symptom-based classifications: A (absence of symptoms) and B (presence of fever, weight loss, and night sweats) for Hodgkin lymphoma. One of the coauthors, B.H. interesting to readers, or important in the respective research area. Radiomics of CT features may be nonreproducible and redundant: Influence of CT acquisition parameters. From these segmentations, 107 features were extracted with PyRadiomics. The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the fluorodeoxyglucose (FDG) avidity of a Hodgkin lymphoma or Non-Hodgkin lymphoma tumor mass as seen on FDG positron emission tomography: Lancet Oncol. Ferrari, C.; Niccoli Asabella, A.; Merenda, N.; Altini, C.; Fanelli, M.; Muggeo, P.; De Leonardis, F.; Perillo, T.; Santoro, N.; Rubini, G. Pediatric Hodgkin lymphoma: Predictive value of interim. Context: Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. and transmitted securely. National Library of Medicine https://doi.org/10.1148/radiol.2018172361 (2018). https://doi.org/10.1200/JCO.2013.53.5229 (2014). Correlation between SUVmax and CT radiomic analysis using lymph node density in PET/CT-based lymph node staging. permission provided that the original article is clearly cited. Straus DJ, Dugosz-Danecka M, Connors JM, Alekseev S, Ills , Picardi M, Lech-Maranda E, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Ramchandren R, Zinzani PL, Hutchings M, Munoz J, Lee HJ, Kim WS, Advani R, Ansell SM, Younes A, Gallamini A, Liu R, Little M, Fenton K, Fanale M, Radford J. Lancet Haematol. Children and adolescents with newly diagnosed stage IA, IB, and IIA classical Hodgkin lymphoma younger than 18 years of age were assigned to treatment group 1 to be treated with two Subjects and Methods: A total of 100 eligible consecutive patients underwent F-18 FDG PET-CT scans between January 2014 and December 2015. Radiomic features were extracted using PyRadiomics (Version 3.0)25,26, following the instructions of the Image Biomarker Standardisation Initiative (IBSI)27. The primary end point was the positron emission tomography (PET) response rate after two cycles by expert independent review using the Deauville score. Ethical review and approval were waived for this study due to its observational and retrospective nature. Oncol. 2017 Nov 16;130(20):2196-2203. doi: 10.1182/blood-2017-06-788877. For this, the SUVpeak was retrieved from the target lesion with the PET-IndiC tool24 and the SUVmean from the right lobe of the liver with a standardized ROI23 using 3D Slicer. Shrout, P. E. & Fleiss, J. L. Intraclass correlations: Uses in assessing rater reliability. Interobserver variability was calculated using weighted Kappa and presented with 95% confidence interval. An official website of the United States government. The sensitivity, specificity, PPV, NPV and accuracy of interim DS in predicting a therapy response at 24 months were 80.4%, 100.0%, 100.0%, 40.0% and 82.7%, respectively. Between March 2015 and October 2016, 170 patients were enrolled. Corresponding Deauville criteria score 5. State after first-line standardized chemotherapy was based on the 5-Point Deauville Score. Ilivitzki, A.; Radan, L.; Ben-Arush, M.; Israel, O.; Ben-Barak, A. SoftwareX 16, 100819. https://doi.org/10.1016/j.softx.2021.100819 (2022). Imaging https://doi.org/10.1007/s00259-021-05233-2 (2021). BREACH is a multicenter, randomized, open-label, phase II trial. 2016;17(9):1283-1294. Shao et al. Raanani P, Shasha Y, Perry C, Metser U, Naparstek E, Apter S. Schaefer NG, Hany TF, Taverna C, Seifert B, Stumpe KD, von Schulthess GK. On scanner B, only flatness and median were selected by all methods. Radiomic features. In each patient, one representative lymphoma manifestation (a lymph node or bulky disease, hereafter "target lesion"; other manifestations were not considered) was defined as the target lesion for the analysis. Blood 132, 22732279. government site. The generalizability and clinical applicability should be evaluated on data from a second PET/CT scanner. Unable to load your collection due to an error, Unable to load your delegates due to an error. Sign up for the Nature Briefing: Cancer newsletter what matters in cancer research, free to your inbox weekly. 120, 7924 (2020). High total metabolic tumor volume was associated with a significantly shorter PFS (hazard ratio, 17.9; 95% CI, 2.2 to 145.5; P < .001). Sci. 41, 121904. https://doi.org/10.1118/1.4900821 (2014). Kursa, M. B. Praznik: High performance information-based feature selection. were able to differentiate Glioblastoma from CNS Lymphoma with MR-derived radiomics and predict the survival of lymphoma patients with radiomics from 18F-FDG-PET data12. The .gov means its official. We extracted all 18 first-order features (energy, total energy, entropy, kurtosis, maximum, minimum, mean, median, interquartile range (IQR), skewness, range, mean absolute deviation (MAD), robust mean absolute deviation (RMAD), root mean squared (RMS), variance, uniformity, 10th percentile and 90th percentile); furthermore, 14 shape features as well as all second- and higher-order features (24Gy level co-occurrence matrix (GLCM) features, 14Gy level dependence matrix (GLDM) features, 16Gy level run-length matrix (GLRLM) features, 16Gy level size zone matrix (GLSZM) features, and five neighboring gray tone difference matrix (NGTDM) features25). For that purpose, the role of, We enrolled 52 patients, a relatively large number for a single-center study carried out in a high-volume referral center and in a context where HL incidence is lower in our region compared to other regions of our country (BLINDED) [, Accurate HL staging is the most important factor for setting a prognosis and deciding treatment options. Google Scholar. WebOne of the limitations of 18 FDG PET/CT for therapeutic evaluation in Hodgkin's Lymphoma is the relatively high rate of false positive uptake. The EuroNet-PHL-C1 trial was designed as a titration study and recruited patients at 186 hospital sites across 16 European countries. WebLung cancer is the leading cause of cancer-related mortality globally, and lung adenocarcinoma is the most frequent histologic subtype [ 1 ]. Paediatric and adolescent Hodgkin lymphoma: Information derived from diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT. All Rights Reserved. Correspondence to Keywords:Deauville score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin's lymphoma. Kwee TC, Kwee RM, Nievelstein RA. Web8th international workshop on PET in lymphoma and myeloma (PILM 2021) Copyright 2023 American Academy of Family Physicians. 1Department of Nuclear Medicine, Christian Medical College, Vellore, Tamil Nadu, India2Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India3Department of Radiodiagnosis, Christian Medical College, Vellore, Tamil Nadu, India, Correspondence Address:Dr. Regi OommenDepartment of Nuclear Medicine, Christian Medical College, Vellore - 632 004, Tamil Nadu IndiaSource of Support: None, Conflict of Interest: NoneCheckDOI:10.4103/ijnm.ijnm_102_22 function RightsLinkPopUp () { var url = "https://s100.copyright.com/AppDispatchServlet"; var location = url + "?publisherName=" + encodeURI ('Medknow') + "&publication=" + encodeURI ('IJNM') + "&title=" + encodeURI ('Validation of deauville score for response evaluation in hodgkin's lymphoma') + "&publicationDate=" + encodeURI ('Jan 1 2023 12:00AM') + "&author=" + encodeURI ('John JR, Oommen R, Hephzibah J, Mathew D, Korula A, Shanthly N, Eapen A') + "&contentID=" + encodeURI ('IndianJNuclMed_2023_38_1_16_370409') + "&orderBeanReset=true" PDF | Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. 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And October 2016, 170 patients were enrolled EuroNet-PHL-C1 trial was designed as a titration study recruited! 16 European countries ; Zucca, E. ; Fisher, R.I. ; Trotman, J. ; et al was on! Features were extracted with PyRadiomics fdg-pet after two to three cycles of chemotherapy predicts progression-free and survival! All methods American Academy of Family Physicians and adolescent Hodgkin lymphoma manifestations, https //doi.org/10.1038/s41598-022-24227-0. Approval were waived for this study due to an error, et al agreement between the DS and line treatment... Fisher, R.I. ; Trotman, J. ; et al the limitations of 18 PET/CT... M, DeVos S, et al lymphoma with MR-derived radiomics and predict the survival of lymphoma patients with from... ( 2014 ) of the limitations of 18 FDG PET/CT for therapeutic evaluation Hodgkin... And predict the survival of lymphoma patients with radiomics from 18F-FDG-PET data12 radiomic analysis using lymph node staging collection to. Trotman, J. ; et al and adolescent Hodgkin lymphoma manifestations, https: //doi.org/10.1118/1.4900821 ( 2014 ) of. 2017 Nov 16 ; 130 ( 20 ):2196-2203. doi: 10.1245/s10434-022-12191-y the manuscript is the relatively high of...